Literature summary for 2.7.4.21 extracted from

Morrison, B.H.; Bauer, J.A.; Lupica, J.A.; Tang, Z.; Schmidt, H.; DiDonato, J.A.; Lindner, D.J.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation (2007), J. Biol. Chem., 282, 15349-15356.

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Activating Compound

Activating Compound	Comment	Organism	Structure
interferon beta	treatment with interferon beta enhances binding of IHPK2 to TNF receptor-associated factor 2	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in NIH-OVCAR-3 cells	Homo sapiens
overexpression of wild-type and inactive mutant IHPK2 in ovarian carcinoma cell lines	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of an inactive enzyme mutant, overexpression of wild-type IHPK2 sensitizes ovarian carcinoma cell lines to the growth-suppressive and apoptotic effects of interferon beta, IFN-alpha2, and gamma-irradiation. Expression of a kinase-dead mutant abrogates 50% of the apoptosis induced by IFN-beta	Mus musculus
S347A/S359A	no IHPK2 activity	Homo sapiens
S347A/S359A	site-directed mutagenesis, the mutant displays 3.5fold greater TAK1 activation following TNF-alpha, the mutant demonstrates a 6-10fold increase in NF-kappaB DNA binding following TNF-alpha compared with wild type IHPK2-expressing cells in which NF-kappa B DNA binding is inhibited	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	IHPK2 binds to tumor necrosis factor receptor-associated factor 2 and interferes with phosphorylation of transforming growth factor beta-activated kinase 1, TAK1, thereby inhibiting NF-kappaB signaling. IHPK2 contains two sites required for TRAF2 binding, Ser347 and Ser359. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappa B-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. A portion of the death-promoting function of IHPK2 is independent of its kinase activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	IHPK2 binds to tumor necrosis factor receptor-associated factor 2 and interferes with phosphorylation of transforming growth factor beta-activated kinase 1, TAK1, thereby inhibiting NF-kappaB signaling. IHPK2 contains two sites required for TRAF2 binding, Ser347 and Ser359. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappa B-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. A portion of the death-promoting function of IHPK2 is independent of its kinase activity	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
IHPK2	-	Mus musculus
IHPK2	-	Homo sapiens
inositol hexakisphosphate kinase 2	-	Mus musculus
inositol hexakisphosphate kinase 2	-	Homo sapiens

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Release 2023.1 (January 2023)