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Literature summary for 2.7.4.14 extracted from
- Identification of human UMP/CMP kinase 1 as doxorubicin binding target using protein microarray (2017), SLAS Discov., 22, 1007-1015 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| doxorubicin | binding of doxorubicin to the enzyme (CMPK1) activates the phosphorylation of CMP, dCMP, and UMP. Doxorubicin might bind to the nonactive site of CMPK1 and regulate its activity with magnesium | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P30085 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
| ATP + dCMP | - |
Homo sapiens | ADP + dCDP | - |
? | |
| ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CMPK1 | - |
Homo sapiens |
| UMP/CMP kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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