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Literature summary for 2.7.4.14 extracted from

  • Zhou, L.; Thornburg, R.
    Site-specific mutations of conserved residues in the phosphate-binding loop of the Arabidopsis UMP/CMP kinase alter ATP and UMP binding (1998), Arch. Biochem. Biophys., 358, 297-302.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G21A mutant enzyme is degraded during the purification phase Arabidopsis thaliana
G22A mutant enzyme with decreased turnover-number/KmATP value. Turnover-number is 59% of that of the wild-type enzyme Arabidopsis thaliana
G24A mutant enzyme with decreased turnover-number/KmATP value. Turnover-number is 48% of that of the wild-type enzyme Arabidopsis thaliana
G26A mutant enzyme with decreased turnover-number/KmATP value Arabidopsis thaliana
G27R mutant enzyme is degraded during the purification phase. Turnover-number is 45% of that of the wild-type enzyme Arabidopsis thaliana
K27E mutant enzyme with 2600fold decreased turnover-number/KmATP value. Turnover-number is 21% of that of the wild-type enzyme Arabidopsis thaliana
K27M mutant enzyme with 1000fold decreased turnover-number/KmATP value. Turnover-number is 22% of that of the wild-type enzyme Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CMP
-
Arabidopsis thaliana ADP + CDP
-
?
ATP + UMP
-
Arabidopsis thaliana ADP + UDP
-
?