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Literature summary for 2.7.4.1 extracted from

  • Price-Carter, M.; Fazzio, T.G.; Vallbona, E.I.; Roth, J.R.
    Polyphosphate kinase protects Salmonella enterica from weak organic acid stress (2005), J. Bacteriol., 187, 3088-3099.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + (phosphate)n+1 Salmonella enterica the enzyme protects Salmonella enterica from weak organic acid stress. Polyphosphate may acts as a chemical chaperone that helps refold homoserine transsuccinylase and/or may stimulate proteolysis of toxic denatured protein. The instability of homoserine transsuccinylase may provide a metabolic fuse that blocks growth under conditions that denature proteins. The sensitivity of this fuse is modulated by polyphosphate ATP + (phosphate)n
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Organism

Organism UniProt Comment Textmining
Salmonella enterica
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + (phosphate)n+1 the enzyme protects Salmonella enterica from weak organic acid stress. Polyphosphate may acts as a chemical chaperone that helps refold homoserine transsuccinylase and/or may stimulate proteolysis of toxic denatured protein. The instability of homoserine transsuccinylase may provide a metabolic fuse that blocks growth under conditions that denature proteins. The sensitivity of this fuse is modulated by polyphosphate Salmonella enterica ATP + (phosphate)n
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