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Literature summary for 2.7.3.2 extracted from

  • Horjus, D.L.; Nieuwland, R.; Boateng, K.B.; Schaap, M.C.; van Montfrans, G.A.; Clark, J.F.; Sturk, A.; Brewster, L.M.
    Creatine kinase inhibits ADP-induced platelet aggregation (2014), Sci. Rep., 4, 6551.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.3.2

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + creatine Homo sapiens
-
 ADP + phosphocreatine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P06732
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma the inter-individual variation in creatine kinase activity in the general population is wide, ranging from below 25 to up to 5000 IU/L5, with particularly high levels in men and in persons of African ancestry Homo sapiens
-
brain
-
 Homo sapiens
-
cardiac muscle
-
 Homo sapiens
-
additional information high creatine kinase activity commonly occurs after exercise and in patients with damage of CK-rich tissue, including cardiac muscle, brain, and skeletal muscle Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + creatine
-
 Homo sapiens ADP + phosphocreatine
-
 r

Synonyms

Synonyms Comment Organism
CK MM
-
 Homo sapiens
creatine kinase M-type
-
 Homo sapiens
plasma creatine kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function creatine kinase inhibits ADP-induced platelet aggregation. Inter-individual differences in plasma creatine kinase activity modulate the bleeding risk. Proposed mode of action of creatine kinase in main inhibitory pathways of platelet activation and the potential role of plasma creatine kinase herein, overview. The enzyme might attenuate platelet activation through scavenging plasma ADP as a binding protein, or via its catalytic activity converting ADP to ATP, leading to a reduced activation of the P2Y12 ADP receptor and attenuated platelet aggregation Homo sapiens