Literature summary for 2.7.3.2 extracted from

Yerlykina, E.I.; Sergeeva, T.F.
Enzymatic characteristics of creatine kinase system under conditions of cerebral circulatory disorders (2010), Bull. Exp. Biol. Med., 149, 14-17.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	in mitochondria from intact animals, mCK exists as a mixture of two oligomeric forms (dimer and octamer: 68 and 32%, respectively)	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Subunits

Subunits	Comment	Organism
oligomer	in mitochondria from intact animals, mCK exists as a mixture of two oligomeric forms (dimer and octamer: 68 and 32%, respectively). Cerebral ischemia changes the dimer/octamer ratio. This ratio is shifted toward the formation of dimers after 30-min ischemia	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
MCK	-	Rattus norvegicus
mitochondrial creatine kinase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	cerebral ischemia is accompanied by opposite changes in activities of mitochondrial creatine kinase (mCK) and cytoplasmic creatine kinase (cCK). Catalytic properties of mCK depend on the functional interaction with mitochondrial membranes. Acute ischemia impairs enzyme interaction with the mitochondrial membrane. These changes manifest in activation of mCK and change in the dimer/octamer ratio toward the formation of octamer. Mitochondrial creatine kinase gains new properties under conditions of oxygen eficiency in nerve cells	Rattus norvegicus

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Release 2023.1 (January 2023)