Literature summary for 2.7.3.2 extracted from

Mu, H.; Lue, Z.R.; Park, D.; Kim, B.C.; Bhak, J.; Zou, F.; Yang, J.M.; Li, S.; Park, Y.D.; Zou, H.C.; Zhou, H.M.
Kinetics of Zn2+-induced brain type creatine kinase unfolding and aggregation (2010), Appl. Biochem. Biotechnol., 160, 1309-1320.

Search for more literature for 2.7.3.2

Inhibitors

Inhibitors	Comment	Organism	Structure
Zn2+	Zn2+ may induce CK-BB inactivation and misfolding, when the Zn2+ concentration is 0.4 mM, CK-BB activity is completely abolished	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
DEAE Sepharose column chromatography and Sephadex G-200 gel filtration	Oryctolagus cuniculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Oryctolagus cuniculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.99	-	crude homogenate	Oryctolagus cuniculus
205.1	-	after 68.6fold purification	Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + creatine	-	Oryctolagus cuniculus	ADP + creatine phosphate	-	r

Synonyms

Synonyms	Comment	Organism
ATP: creatine N-phosphotransferase	-	Oryctolagus cuniculus
brain type creatine kinase	-	Oryctolagus cuniculus
CK-BB	-	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Oryctolagus cuniculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.15	-	at 25°C	Oryctolagus cuniculus	Zn2+

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Release 2023.1 (January 2023)