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Literature summary for 2.7.3.2 extracted from

  • Wennefors, C.K.; Dobrikov, M.I.; Xu, Z.; Li, P.; Shaw, B.R.
    Stereospecificity, substrate, and inhibitory properties of nucleoside diphosphate analogs for creatine and pyruvate kinases (2008), Bioorg. Chem., 36, 169-177.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-P-borano substituted ADP Sp isomer strong competitive inhibitor Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
alpha-(SP)-borano substituted ADP
-
Oryctolagus cuniculus
0.067
-
ADP
-
Oryctolagus cuniculus
1
-
alpha-(RP)-borano substituted ADP
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphocreatine
-
Oryctolagus cuniculus ATP + creatine
-
?
alpha-(RP)-borano-ADP + phosphocreatine the SP-ADPalphaB isomer is a 70fold better substrate for creatine kinase than the RP isomer Oryctolagus cuniculus alpha-(RP)-borano-ATP + creatine
-
?
alpha-(SP)-borano-ADP + phosphocreatine the SP-ADPalphaB isomer is a 70fold better substrate for creatine kinase than the RP isomer Oryctolagus cuniculus alpha-(SP)-borano-ATP + creatine
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.03
-
alpha-(SP)-borano substituted ADP
-
Oryctolagus cuniculus
0.06
-
alpha-(RP)-borano substituted ADP
-
Oryctolagus cuniculus
370
-
ADP
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.049
-
alpha-P-borano substituted ADP Sp isomer
-
Oryctolagus cuniculus