Literature summary for 2.7.3.2 extracted from

Barschak, A.G.; Ferreira, G.D.; Andre, K.R.; Schuck, P.F.; Viegas, C.M.; Tonin, A.; Filho, C.S.; Wyse, A.T.; Wannmacher, C.M.; Vargas, C.R.; Wajner, M.
Inhibition of the electron transport chain and creatine kinase activity by ethylmalonic acid in human skeletal muscle (2006), Metab. Brain Dis., 21, 11-19.

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Application

Application	Comment	Organism
medicine	ethylmalonic acid accumulates in patients affected by short-chain acyl-CoA dehydrogenase deficiency and other diseases. Ethylmalonic acid inhibits the activity of respiratory chain complexes and also inhibits creatine kinase at concentrations o 1 mM and 5 mM and may therefore compromise energy metabolism in skeletal muscle	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
ethylmalonic acid	accumulation in patients affected by short-chain acyl-CoA dehydrogenase deficiency and other diseases. Ethylmalonic acid inhibits the activity of respiratory chain complexes and also inhibits creatine kinase at concentrations o 1 mM and 5 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Homo sapiens	-

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Release 2023.1 (January 2023)