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Literature summary for 2.7.3.2 extracted from

  • Eliuk, S.M.; Renfrow, M.B.; Shonsey, E.M.; Barnes, S.; Kim, H.
    Active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: mapping of modified sites by Fourier transform-ion cyclotron resonance mass spectrometry (2007), Chem. Res. Toxicol., 20, 1260-1268.
    View publication on PubMed

Application

Application Comment Organism
medicine levels of both free and protein-bound 4-hydroxy-2-nonenal are increased in alzheimer’s disease brain. 4-Hydroxy-2-nonenal inhibitis creatine kinase dose-dependently and forms adducts with specific amino acids including the active site residues H66, H191, C283, and H296 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-2-nonenal dose-dependent inhibition of creatine kinase, inhibition correlates with 4-hydroxy-2-nonenal adduct formation on specific amino acid residues including the active site residues H66, H191, C283, and H296 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with Alzheimer’s disease
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-