Application | Comment | Organism |
---|---|---|
medicine | levels of both free and protein-bound 4-hydroxy-2-nonenal are increased in alzheimers disease brain. 4-Hydroxy-2-nonenal inhibitis creatine kinase dose-dependently and forms adducts with specific amino acids including the active site residues H66, H191, C283, and H296 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-2-nonenal | dose-dependent inhibition of creatine kinase, inhibition correlates with 4-hydroxy-2-nonenal adduct formation on specific amino acid residues including the active site residues H66, H191, C283, and H296 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with Alzheimers disease | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |