Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | 70.9% inhibition of the atypical ubiquitous mitochondrial enzyme, 74.6% inhibition of the typical ubiquitous mitochondrial enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.69 | - |
Creatine | 37°C, atypical ubiquitous mitochondrial enzyme | Homo sapiens | |
0.74 | - |
Creatine | 37°C, typical ubiquitous mitochondrial enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + creatine | Homo sapiens | - |
ADP + phosphocreatine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
2 typical mitochondrial enzyme types, the sarcomeric and the ubiquitous, encoded by 2 different genes | - |
Purification (Comment) | Organism |
---|---|
typical ubiquitous mitochondrial enzyme from heart muscle tissue, atypical ubiquitous mitochondrial from serum | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
serum | patient with ovarian hepatoid yolk sac tumor, an atypical ubiquitous mitochondrial enzyme form | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + creatine | - |
Homo sapiens | ADP + phosphocreatine | - |
r |
Synonyms | Comment | Organism |
---|---|---|
creatine N-phosphotransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
20 min, 88.1% remaining activity of the atypical ubiquitous mitochondrial enzyme, 89.6% remaining activity of the typical ubiquitous mitochondrial enzyme | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | the enzyme from serum of a patient with ovarian hepatoid yolk sac tumor shows an atypical pI value compared to enzyme from other, healthy tissue, overview | - |
additional information |
Homo sapiens | several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing | - |
6.8 |
Homo sapiens | ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing | - |
6.9 |
Homo sapiens | ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing | - |
7 |
Homo sapiens | several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing | 7.8 | 7 |