Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.3.2 extracted from

  • Kanemitsu, F.; Kageoka, T.; Kira, S.
    Mitochondrial creatine kinase with atypical pI values detected in serum of a patient with ovarian hepatoid yolk sac tumor (2003), J. Chromatogr. B, 783, 191-197.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide 70.9% inhibition of the atypical ubiquitous mitochondrial enzyme, 74.6% inhibition of the typical ubiquitous mitochondrial enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.69
-
Creatine 37°C, atypical ubiquitous mitochondrial enzyme Homo sapiens
0.74
-
Creatine 37°C, typical ubiquitous mitochondrial enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + creatine Homo sapiens
-
ADP + phosphocreatine
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 typical mitochondrial enzyme types, the sarcomeric and the ubiquitous, encoded by 2 different genes
-

Purification (Commentary)

Purification (Comment) Organism
typical ubiquitous mitochondrial enzyme from heart muscle tissue, atypical ubiquitous mitochondrial from serum Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
serum patient with ovarian hepatoid yolk sac tumor, an atypical ubiquitous mitochondrial enzyme form Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + creatine
-
Homo sapiens ADP + phosphocreatine
-
r

Synonyms

Synonyms Comment Organism
creatine N-phosphotransferase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
20 min, 88.1% remaining activity of the atypical ubiquitous mitochondrial enzyme, 89.6% remaining activity of the typical ubiquitous mitochondrial enzyme Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 9
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens the enzyme from serum of a patient with ovarian hepatoid yolk sac tumor shows an atypical pI value compared to enzyme from other, healthy tissue, overview
-
additional information
Homo sapiens several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing
-
6.8
Homo sapiens ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing
-
6.9
Homo sapiens ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing
-
7
Homo sapiens several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing 7.8 7