Protein Variants | Comment | Organism |
---|---|---|
D162E | about 0.1% of wild-type activity | Escherichia coli |
K8R | substantial although diminished activity | Escherichia coli |
N158K | substantial although diminished activity | Escherichia coli |
R66K | substantial although diminished activity | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
N-acetyl-L-glutamate | wild-type, pH 7.0, 25°C | Escherichia coli | |
0.29 | - |
ATP | wild-type, pH 7.0, 25°C | Escherichia coli | |
0.37 | - |
N-acetyl-L-glutamate | mutant D162E, pH 7.0, 25°C | Escherichia coli | |
0.46 | - |
ATP | mutant D162E, pH 7.0, 25°C | Escherichia coli | |
2.3 | - |
N-acetyl-L-glutamate | mutant K8R, pH 7.0, 25°C | Escherichia coli | |
3.3 | - |
ATP | mutant K8R, pH 7.0, 25°C | Escherichia coli | |
5.2 | - |
ATP | mutant R66K, pH 7.0, 25°C | Escherichia coli | |
7.9 | - |
ATP | mutant N158Q, pH 7.0, 25°C | Escherichia coli | |
600 | - |
N-acetyl-L-glutamate | mutant N158Q, pH 7.0, 25°C | Escherichia coli | |
898 | - |
N-acetyl-L-glutamate | mutant R66K, pH 7.0, 25°C | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A6C8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acetyl-L-glutamate | - |
Escherichia coli | ADP + N-acetyl-L-glutamate 5-phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
30.4 | - |
ATP | wild-type, pH 7.0, 25°C | Escherichia coli | |
41.5 | - |
ATP | mutant N158Q, pH 7.0, 25°C | Escherichia coli |