Literature summary for 2.7.2.4 extracted from

Yang, Q.Q.; Yu, W.H.; Wu, H.Y.; Zhang, C.Q.; Sun, S.S.; Liu, Q.Q.
Lysine biofortification in rice by modulating feedback inhibition of aspartate kinase and dihydrodipicolinate synthase (2021), Plant Biotechnol. J., 19, 490-501 .

Search for more literature for 2.7.2.4

Application

Application	Comment	Organism
nutrition	enzyme mutants may be used to improve the nutritional quality of rice and other cereal grains	Oryza sativa Japonica Group

Cloned(Commentary)

Cloned (Comment)	Organism
mutant enzymes are expressed in Escherichia coli BL21 cells	Oryza sativa Japonica Group

Protein Variants

Protein Variants	Comment	Organism
S449L	transgenic plants expressing the mutant enzyme show a 6.6fold increased free lysine content	Oryza sativa Japonica Group
T448M	transgenic plants expressing the mutant enzyme show about 2fold increased free lysine content	Oryza sativa Japonica Group

Inhibitors

Inhibitors	Comment	Organism	Structure
L-lysine	-	Oryza sativa Japonica Group
L-threonine	-	Oryza sativa Japonica Group
additional information	insensitive to S-(2-aminoethyl)-L-cysteine at concentrations up to 12 mM	Oryza sativa Japonica Group

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-aspartate	Oryza sativa Japonica Group	-	ADP + 4-phospho-L-aspartate	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryza sativa Japonica Group	Q5JK18	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-aspartate	-	Oryza sativa Japonica Group	ADP + 4-phospho-L-aspartate	-	?

Synonyms

Synonyms	Comment	Organism
lysC	-	Oryza sativa Japonica Group

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Release 2023.1 (January 2023)