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Literature summary for 2.7.2.4 extracted from
- Phylogenetic and disruption analyses of aspartate kinase of Deinococcus radiodurans (2007), Biosci. Biotechnol. Biochem., 71, 1015-1020.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | AK DR1365 is not used for lysine biosynthesis but for threonine and methionine biosynteses, AK TTC0166 in Thermus thermophilus and AK DR1365 in Deinococcus radiodurans have different protein structure and evolutionary origins, but their functions are not different | Deinococcus radiodurans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DR1365 gene of Deinococcus radiodurans is isolated, after PCR amplification and several steps the amplified DNA fragment is introduced into Deinococcus radiodurans ATCC13939 to generate a DR1365 disruptant. | Deinococcus radiodurans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| DR1365 | disruption mutant does not grow in the minimal medium, Deinococcus radiodurans uses DR1365 for biosyntheses of methionine and threonine, but does not use it for lysine biosynthesis, the growth rate is lower than that of the wild type | Deinococcus radiodurans |
| additional information | AK DR1365 disruption mutant, does not grow in minimal medium, growth rate in minimal medium supplemented with methionine and threonine is identical to that supplemented with methionine, threonine and lysine, this phenotype is similar to a Thermus thermophilus AK TTC0166 disprution mutant | Deinococcus radiodurans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate | Deinococcus radiodurans | disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses | ADP + 4-phospho-L-aspartate | - |
? |  |
| ATP + L-aspartate | Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses | ADP + 4-phospho-L-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Deinococcus radiodurans | - |
- |
- |
| Deinococcus radiodurans | Q9RUL9 | Deinococcus radiodurans AK has a different protein structure and a different evolutionary history from Thermus thermophilus AK, the disruption mutant exhibits a similar phenotype and the functions are not different | - |
| Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | - |
- |
- |
| Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | Q9RUL9 | Deinococcus radiodurans AK has a different protein structure and a different evolutionary history from Thermus thermophilus AK, the disruption mutant exhibits a similar phenotype and the functions are not different | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate | disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses | Deinococcus radiodurans | ADP + 4-phospho-L-aspartate | - |
? | |
| ATP + L-aspartate | disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses | Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | ADP + 4-phospho-L-aspartate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AK | - |
Deinococcus radiodurans |
| aspartate kinase | - |
Deinococcus radiodurans |
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