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Literature summary for 2.7.2.3 extracted from

  • Lam, W.; Bussom, S.; Cheng, Y.C.
    Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma (2009), Mol. Cancer Ther., 8, 415-423.
    View publication on PubMed
Search for more literature for 2.7.2.3

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm hypoxia has no effect on the subcellular distribution of the PGK protein Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information H460 cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphorylates beta-L-dioxolane-cytidine, a novel L-configuration deoxycytidine analogue, under clinical trials for treating cancer Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PGK
-
 Homo sapiens
phosphoglycerate kinase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in culture, hypoxic treatment induces protein expression of PGK by 3fold but has no effect on the protein expression of other beta-L-dioxolane-cytidine metabolism-associated enzymes such as apurinic/apyrimidinic endonuclease-1, deoxycytidine kinase, CMP kinase, and nM23 H1. Expression of PGK increases as the tumor size increases. PGK protein expression has a positive correlation to HIF-1alpha up