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Literature summary for 2.7.2.3 extracted from

  • Szabo, J.; Varga, A.; Flachner, B.; Konarev, P.V.; Svergun, D.I.; Zavodszky, P.; Vas, M.
    Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase (2008), FEBS Lett., 582, 1335-1340.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E192A kcat/Km for ATP is 11.7fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 58.6fold lower than wild-type value Homo sapiens
F165A kcat/Km for ATP is 23fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 60.7fold lower than wild-type value Homo sapiens
F196A kcat/Km for ATP is 4.2fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 19.3fold lower than wild-type value Homo sapiens
S392A kcat/Km for ATP is 1.03fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 9.4fold lower than wild-type value Homo sapiens
S392A/T393A kcat/Km for ATP is 304fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 1717fold lower than wild-type value Homo sapiens
S398A kcat/Km for ATP is 1.13fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 5.3fold lower than wild-type value Homo sapiens
T393A kcat/Km for ATP is 113fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 288fold lower than wild-type value Homo sapiens
T393del kcat/Km for ATP is 14615fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 27869fold lower than wild-type value Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
3-phospho-D-glyceroyl phosphate wild-type enzyme Homo sapiens
0.0091
-
3-phospho-D-glyceroyl phosphate mutant enzyme E192A Homo sapiens
0.01
-
3-phospho-D-glyceroyl phosphate mutant enzyme T393A Homo sapiens
0.017
-
3-phospho-D-glyceroyl phosphate mutant enzyme F165A Homo sapiens
0.03
-
ATP mutant enzyme S398A Homo sapiens
0.05
-
3-phospho-D-glycerate wild-type enzyme Homo sapiens
0.062
-
3-phospho-D-glycerate mutant enzyme S398A Homo sapiens
0.078
-
ATP mutant enzyme S392A Homo sapiens
0.09
-
ADP mutant enzyme E192A Homo sapiens
0.1
-
ADP mutant enzyme T393A Homo sapiens
0.11
-
ATP wild-type enzyme Homo sapiens
0.11
-
3-phospho-D-glycerate mutant enzyme T393del Homo sapiens
0.12
-
ADP wild-type enzyme Homo sapiens
0.12
-
ADP mutant enzyme F165A Homo sapiens
0.13
-
ATP mutant enzyme T393del Homo sapiens
0.24
-
ATP mutant enzyme E192A Homo sapiens
0.32
-
3-phospho-D-glycerate mutant enzyme S392A Homo sapiens
0.33
-
ATP mutant enzyme F196A Homo sapiens
0.53
-
3-phospho-D-glycerate mutant enzyme E192A Homo sapiens
0.66
-
ATP mutant enzyme S392A/T393A Homo sapiens
0.69
-
3-phospho-D-glycerate mutant enzyme F196A Homo sapiens
0.83
-
ATP mutant enzyme F165A Homo sapiens
0.86
-
ATP mutant enzyme T393A Homo sapiens
0.95
-
3-phospho-D-glycerate mutant enzyme F165A Homo sapiens
0.99
-
3-phospho-D-glycerate mutant enzyme T393A Homo sapiens
1.66
-
3-phospho-D-glycerate mutant enzyme S392A/T393A Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + 3-phospho-D-glyceroyl phosphate
-
Homo sapiens ATP + 3-phospho-D-glycerate
-
?

Synonyms

Synonyms Comment Organism
3-phosphoglycerate kinase
-
Homo sapiens
hPGK
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.067
-
ATP mutant enzyme T393del Homo sapiens
0.067
-
3-phospho-D-glycerate mutant enzyme T393del Homo sapiens
16.4
-
ATP mutant enzyme S392A/T393A Homo sapiens
16.4
-
3-phospho-D-glycerate mutant enzyme S392A/T393A Homo sapiens
58
-
ATP mutant enzyme T393A Homo sapiens
58
-
3-phospho-D-glycerate mutant enzyme T393A Homo sapiens
155
-
ATP mutant enzyme E192A Homo sapiens
155
-
3-phospho-D-glycerate mutant enzyme E192A Homo sapiens
200
-
ATP mutant enzyme S398A Homo sapiens
200
-
3-phospho-D-glycerate mutant enzyme S398A Homo sapiens
250
-
ADP mutant enzyme T393A Homo sapiens
250
-
3-phospho-D-glyceroyl phosphate mutant enzyme T393A Homo sapiens
270
-
ATP mutant enzyme F165A Homo sapiens
270
-
3-phospho-D-glycerate mutant enzyme F165A Homo sapiens
575
-
ATP mutant enzyme S392A Homo sapiens
575
-
3-phospho-D-glycerate mutant enzyme S392A Homo sapiens
610
-
ATP mutant enzyme F196A Homo sapiens
610
-
3-phospho-D-glycerate mutant enzyme F196A Homo sapiens
833
-
ATP wild-type enzyme Homo sapiens
833
-
3-phospho-D-glycerate wild-type enzyme Homo sapiens
1130
-
ADP mutant enzyme E192A Homo sapiens
1130
-
3-phospho-D-glyceroyl phosphate mutant enzyme E192A Homo sapiens
1170
-
ADP mutant enzyme F165A Homo sapiens
1170
-
3-phospho-D-glyceroyl phosphate mutant enzyme F165A Homo sapiens
2630
-
ADP wild-type enzyme Homo sapiens
2630
-
3-phospho-D-glyceroyl phosphate wild-type enzyme Homo sapiens