Cloned (Comment) | Organism |
---|---|
inducible expression of cytosolic isozyme in bloodstream parasites, toxicity depends on the expression level of active enzyme | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | in parasites grown in the gut of tsetse fly | Trypanosoma brucei | 5829 | - |
glycosome | in parasites grown in mammalian bloodstream | Trypanosoma brucei | 20015 | - |
additional information | the catalytically active cytosolic isozyme is toxic and lethal for bloodstream parasites | Trypanosoma brucei | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + 3-phospho-D-glyceroyl phosphate | Trypanosoma brucei | - |
ATP + 3-phospho-D-glycerate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
glycosomal PGKA and cytosolic PGKB isozymes | - |
Trypanosoma brucei | - |
from mammalian blood stream and the gut of tsetse fly | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + 3-phospho-D-glyceroyl phosphate | - |
Trypanosoma brucei | ATP + 3-phospho-D-glycerate | - |
r | |
ATP + 3-phospho-D-glycerate | - |
Trypanosoma brucei | ADP + 1,3-diphosphoglycerate | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Trypanosoma brucei | |
ATP | required as phosphate donor | Trypanosoma brucei |