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Literature summary for 2.7.13.3 extracted from

  • Wilke, K.; Fihn, C.; Carlson, E.
    Screening serine/threonine and tyrosine kinase inhibitors for histidine kinase inhibition (2018), Bioorg. Med. Chem., 26, 5322-5326 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.13.3

Inhibitors

Inhibitors Comment Organism Structure
7-(4-fluorophenyl)-6-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine compound is able to displace ADP-BODIPY from the HK853 ATP-binding domain and inhibits HK853 and Streptococcus pneumoniaeVicK activity at non-aggregating concentrations. Compound may only poorly penetrate the bacterial envelope or lacks sufficient potency to yield measurable effects Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9WZV7
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-
Thermotoga maritima DSM 3109 Q9WZV7
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-

Synonyms

Synonyms Comment Organism
HK853
-
 Thermotoga maritima

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0237
-
 pH not specified in the publication, temperature not specified in the publication Thermotoga maritima 7-(4-fluorophenyl)-6-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine