Literature summary for 2.7.13.3 extracted from

Khorchid, A.; Ikura, M.
Bacterial histidine kinase as signal sensor and transducer (2006), Int. J. Biochem. Cell Biol., 38, 307-312.

Search for more literature for 2.7.13.3

Application

Application	Comment	Organism
medicine	significance in pathological virulence of Salmonella enterica, seductive target for anti-bacterial therapeutic development	Salmonella enterica
additional information	15 of the 30 known Escherichia coli histidine kinases contain a single HAMP domain, has an important role in signal transduction	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	mutations within the linker HAMP domain block the osmosensing function of EnvZ	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
inner membrane	EnvZ with a N-terminal cytoplasmic tail (residues 1-15), two transmembrane domains (residues 16-34 and residues 163-179) flanking a periplasmic domain (residues 48-162), and a cytoplasmic domain (residues 180-450). The cytoplasmic domain can be further dissected into a linker or HAMP domain (residues 180-222), domain A (dimerization and histidine containing domain, residues 223-289) and domain B (catalysis assisting and ATP binding domain, residues 290-450), UhpB contains eight transmembrane segments	Escherichia coli	-	-
membrane	FixL contains four transmembrane segments	Sinorhizobium meliloti	16020	-

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Salmonella enterica	-	-	-
Sinorhizobium meliloti	-	-	-

Synonyms

Synonyms	Comment	Organism
ENVZ	-	Escherichia coli
FixL	-	Sinorhizobium meliloti
histidine kinase	-	Sinorhizobium meliloti
histidine kinase	-	Escherichia coli
histidine kinase	-	Salmonella enterica
UhpB	-	Escherichia coli

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Release 2023.1 (January 2023)