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Literature summary for 2.7.12.2 extracted from

  • Moretti, M.; Rossi, M.; Ciuffo, M.; Turina, M.
    Functional characterization of the three mitogen-activated protein kinase kinases (MAP2Ks) present in the Cryphonectria parasitica genome reveals the necessity of Cpkk1 and Cpkk2, but not Cpkk3, for pathogenesis on chestnut (Castanea spp.) (2014), Mol. Plant Pathol., 15, 500-512.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Protein Variants

Protein Variants Comment Organism
additional information generation of a cpkk1 knockout mutant, abnormal hyphae with a reduced number of septa and thinner cell walls are observed in DELTAcpkk1 mutant. The DELTAcpkk1 strain shows strong sensitivity to digestion and a low level of cell wall resistance. Phenotype, overview Cryphonectria parasitica
additional information generation of a cpkk3 knockout mutant. Growth of DELTAcpkk3 is unaffected in either solid or liquid medium. Phenotype, overview Cryphonectria parasitica
additional information generation of a DELTAcpkk2 knockout mutant showing a strong growth defect on solid media when compared with the control. Phenotype, overview Cryphonectria parasitica

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Cryphonectria parasitica

Organism

Organism UniProt Comment Textmining
Cryphonectria parasitica B2ZAW3 gene cpkk2
-
Cryphonectria parasitica B2ZAW3 gene cpkk3
-
Cryphonectria parasitica O93876 gene cpkk1
-

Source Tissue

Source Tissue Comment Organism Textmining
hypha
-
 Cryphonectria parasitica
-
mycelium no growth of wild-type and mutant strains at 8°C and 37°C Cryphonectria parasitica
-

Synonyms

Synonyms Comment Organism
cpkk1
-
 Cryphonectria parasitica
cpkk2
-
 Cryphonectria parasitica
cpkk3
-
 Cryphonectria parasitica
MAP2K
-
 Cryphonectria parasitica
mitogen-activated protein kinase kinase
-
 Cryphonectria parasitica

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cryphonectria parasitica

General Information

General Information Comment Organism
malfunction virulence on chestnut and the developmental steps essential for mating are not affected in the DELTAcpkk3 strain. No alterations are reported in DELTAcpkk3, except under hyperosmotic conditions and in the presence of fludioxonil. Phenotype, overview Cryphonectria parasitica
malfunction virulence on chestnut is affected in the DELTAcpkk1 strain which is also unable to complete the developmental steps essential for mating. Phenotype, overview Cryphonectria parasitica
malfunction virulence on chestnut is affected in the DELTAcpkk2 strain which is also unable to complete the developmental steps essential for mating. DELTAcpkk2 mutants show higher sensitivity during growth in medium containing the antibiotic G418, i.e. geneticin. Phenotype, overview Cryphonectria parasitica
metabolism Cpkk1, the Mkk1 orthologue, acts in a phosphorylation cascade essential for cell integrity Cryphonectria parasitica
metabolism Cpkk2 is the Ste7 orthologue involved in the pheromone response pathway Cryphonectria parasitica
metabolism Cpkk3 is the Pbs2 orthologue, the MAP2K activates during the high-osmolarity response Cryphonectria parasitica