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Literature summary for 2.7.12.2 extracted from

  • Lee, H.
    Mitogen-activated protein kinase kinase 3 is required for regulation during dark-light transition (2015), Mol. Cells, 38, 651-656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Activating Compound

Activating Compound Comment Organism Structure
additional information light signals activate the MAP kinase via phosphorylation through MAP kinase kinase Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MAP kinase Arabidopsis thaliana activation of MAP kinase ADP + phosphorylated MAP kinase
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O80396
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-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MAP kinase activation of MAP kinase Arabidopsis thaliana ADP + phosphorylated MAP kinase
-
 ?

Synonyms

Synonyms Comment Organism
MAPKK3
-
 Arabidopsis thaliana
mitogen-activated protein kinase kinase 3
-
 Arabidopsis thaliana
MKK3
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction an mkk3 mutant shows both a hypersensitive response in plant hormone gibberellin and a less sensitive response in red light signaling. Light-induced MAPK activation in wild-type seedlings and constitutive MAPK phosphorylation in dark-grown mkk3 mutant seedlings are found, respectively. The mkk3-1 mutant displays a gibberellic acid-hypersensitive phenotype in hypocotyl elongation, with an additiona long petiole phenotype Arabidopsis thaliana
metabolism the mitogen-activated protein kinase (MAPK) cascade usually functions as an important signaling network involved in physiological and developmental processes in eukaryotes. The MAPK cascade is usually composed of sequential activations of three classes of Ser/Thr protein kinases: MAPK (MPK), MAPK kinase (MKK), and MAPK kinase kinase (MKKK). The MAPK kinase (MKK) gene family has relatively few members in canonical MAPK cascade gene families, which are classified into four groups (A to D) based on the sequence similarities Arabidopsis thaliana
physiological function MKK3 acts in negative regulation in darkness and in light-induced MAPK activation during darklight transition Arabidopsis thaliana