Protein Variants | Comment | Organism |
---|---|---|
additional information | exogenous expression in cultured mammalian cells of an MKK7-JNK fusion protein, that functions as a constitutively active form of JNK, induces phosphorylation of PER2, an essential circadian component | Homo sapiens |
additional information | exogenous expression in cultured mammalian cells of an MKK7-JNK fusion protein, that functions as a constitutively active form of JNK, induces phosphorylation of PER2, an essential circadian component | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + c-Jun N-terminal kinase | Homo sapiens | JNK activation | ADP + phosphorylated c-Jun N-terminal kinase | - |
? | |
ATP + c-Jun N-terminal kinase | Mus musculus | JNK activation | ADP + phosphorylated c-Jun N-terminal kinase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14733 | - |
- |
Mus musculus | Q8CE90 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic fibroblast | - |
Mus musculus | - |
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + c-Jun N-terminal kinase | JNK activation | Homo sapiens | ADP + phosphorylated c-Jun N-terminal kinase | - |
? | |
ATP + c-Jun N-terminal kinase | JNK activation | Mus musculus | ADP + phosphorylated c-Jun N-terminal kinase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MKK7 | - |
Homo sapiens |
MKK7 | - |
Mus musculus |
stress kinase mitogen-activated protein kinase kinase 7 | - |
Homo sapiens |
stress kinase mitogen-activated protein kinase kinase 7 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic inactivation of MKK7 results in an extended period of oscillation in circadian gene expression in mouse embryonic fibroblasts, genetic inactivation of the Mkk7 gene alters circadian gene expression | Mus musculus |
malfunction | genetic inactivation of the Mkk7 gene alters circadian gene expression | Homo sapiens |
physiological function | the stress kinase mitogen-activated protein kinase kinase 7 (MKK7) is a specific activator of c-Jun N-terminal kinase (JNK), which controls various physiological processes, such as cell proliferation, apoptosis, differentiation, and migration. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock, overview. JNK interacts with PER2 at both the exogenous and endogenous levels, and MKK7-mediated JNK activation increases the half-life of PER2 protein by inhibiting its ubiquitination. The PER2 protein stabilization induced by MKK7-JNK fusion protein reduces the degradation of PER2 induced by casein kinase 1epsilon. MKK7 controls circadian gene expression in cultured cells | Homo sapiens |
physiological function | the stress kinase mitogen-activated protein kinase kinase 7 (MKK7) is a specific activator of c-Jun N-terminal kinase (JNK), which controls various physiological processes, such as cell proliferation, apoptosis, differentiation, and migration. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock, overview. JNK interacts with PER2 at both the exogenous and endogenous levels, and MKK7-mediated JNK activation increases the half-life of PER2 protein by inhibiting its ubiquitination. The PER2 protein stabilization induced by MKK7-JNK fusion protein reduces the degradation of PER2 induced by casein kinase 1epsilon. MKK7 controls circadian gene expression in cultured cells | Mus musculus |