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Literature summary for 2.7.12.2 extracted from
- Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ERalpha in PC12 cells (2010), J. Neurochem., 112, 42-55.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PD98059 | MEK inhibitor, effective dose of 0.05 mM | Rattus norvegicus |  |
| U0126 | MEK inhibitor, effective dose at 0.1 mM | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + MAPK | Rattus norvegicus | - |
ADP + phosphorylated MAPK | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| PC-12 cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + MAPK | - |
Rattus norvegicus | ADP + phosphorylated MAPK | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAPK/Erk kinase | - |
Rattus norvegicus |
| MEK | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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