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Literature summary for 2.7.12.2 extracted from

  • Kang, N.J.; Lee, K.W.; Lee, D.E.; Rogozin, E.A.; Bode, A.M.; Lee, H.J.; Dong, Z.
    Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase (2008), J. Biol. Chem., 283, 20664-20673.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Inhibitors

Inhibitors Comment Organism Structure
Cocoa procyanidin B2 procyanidin B2 suppresses TPA-induced phosphorylation of MEK, ERK, and p90RSK in JB6 P+ cells, suppresses JB6 P+ cell transformation by inhibiting mitogen-activated protein kinase kinase, molecular mechanism, overview Mus musculus
Cocoa procyanidins suppresses JB6 P+ cell transformation by inhibiting mitogen-activated protein kinase kinase, molecular mechanisms of the chemopreventive potential of cocoa and its active ingredients, overview Mus musculus
additional information no MEK inhibition by theobromine Mus musculus
PD098059 MEK1 inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P31938
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [ERK2 substrate peptide] MEK1 Mus musculus ADP + [ERK2 substrate peptide] phosphate
-
 ?
ATP + [myelin basic protein substrate peptide]
-
 Mus musculus ADP + [myelin basic protein substrate peptide] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
extracellular signal-regulated kinase
-
 Mus musculus
MEK
-
 Mus musculus
MEK1
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus