Literature summary for 2.7.12.2 extracted from

Demuth, T.; Reavie, L.B.; Rennert, J.L.; Nakada, M.; Nakada, S.; Hoelzinger, D.B.; Beaudry, C.E.; Henrichs, A.N.; Anderson, E.M.; Berens, M.E.
MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival (2007), Mol. Cancer Ther., 6, 1212-1222.

Search for more literature for 2.7.12.2

Application

Application	Comment	Organism
medicine	key activator of p38 MAPK in glioma, MKK3 activation is strongly correlated with p38 activation in vitro and in vivo, strong promoter of tumor invasion, progression, and poor patient survival, interference with MKK3 signaling through a novel treatment combination of p38 inhibitor plus temozolomide heightens the vulnerability of glioma to chemotherapy	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	cells transiently transfected with two independent sets of siRNAs show significant down-regulation of MKK3 and phosphorylated MKK3	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P46734	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocytoma cell	MKK3 is a prognostic marker in malignant astrocytomas	Homo sapiens	-
brain	-	Homo sapiens	-
glioma cell	MKK3 i s upregulated and activated in invasive glioma cells in vitro, overexpression and phosphorylation of MKK3 are linked to glioma invasion, MKK3 is overexpressed in invasive glioma cells in situ and correlates with active p38	Homo sapiens	-
additional information	U87 cell, U118 cell, SNB19 cell and U87deltaEGFR cell	Homo sapiens	-
U-251 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MAPK kinase 3	-	Homo sapiens
mitogen-activated protein kinase kinase 3	-	Homo sapiens
MKK3	-	Homo sapiens

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Release 2023.1 (January 2023)