Literature summary for 2.7.12.2 extracted from

Gibbs, G.M.; Bianco, D.M.; Jamsai, D.; Herlihy, A.; Ristevski, S.; Aitken, R.J.; Kretser, D.M.; OBryan, M.K.
Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm (2007), Biol. Reprod., 77, 108-114.

Search for more literature for 2.7.12.2

Application

Application	Comment	Organism
additional information	the carboxyl-most 20 amino acids of MAP3K11 interact with the CRISP domain of CRISP2. CRISP2 may be a MAP3K11-modifying protein or, alternatively, MAP3K11 acts to phosphorylate CRISP2 during acrosome development	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
acrosome	developing spermatids and epididymal spermatozoa, colocalization of MAP3K11 and CRISP2	Mus musculus	-	-
cytoplasm	late spermatocytes and round spermatids	Mus musculus	5737	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
23000	-	fragment of MAP3K11, Western blot analysis	Mus musculus
44000	-	fragment of MAP3K11, Western blot analysis	Mus musculus
60000	-	fragment of MAP3K11 in epididymal sperm, Western blot analysis	Mus musculus
70000	-	fragment of MAP3K11, Western blot analysis	Mus musculus
93000	-	MAP3K11 in somatic tissue, Western blot analysis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	adult F1 mice and postnatal day-14, -22, -30, and -60 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
brain	93000 Da form	Mus musculus	-
epididymis	-	Mus musculus	-
heart	93000 Da form	Mus musculus	-
kidney	-	Mus musculus	-
large intestine	-	Mus musculus	-
Leydig cell	-	Mus musculus	-
liver	44000 Da form	Mus musculus	-
lung	93000 Da form	Mus musculus	-
additional information	not in spermatogonia, early primary spermatocytes, Sertoli cells, or peritubular myoid cells	Mus musculus	-
ovary	-	Mus musculus	-
small intestine	-	Mus musculus	-
sperm	-	Mus musculus	-
spermatid	-	Mus musculus	-
spermatozoon	epididymal spermatozoa, 60000 Da variant of MAP3K11, may be a result of proteolytic cleavage of the longer form	Mus musculus	-
spleen	93000 Da form	Mus musculus	-
stomach	-	Mus musculus	-
testis	93000, 70000, 40000, 23000 Da forms, first MAP3K11 expression detectable at day-14, higher levels of expression at day-30 and day-36	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
MAP3K11	-	Mus musculus
mitogen-activated protein kinase kinase kinase 11	-	Mus musculus

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Release 2023.1 (January 2023)