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Literature summary for 2.7.12.2 extracted from

  • Atwal, J.K.; Singh, K.K.; Tessier-Lavigne, M.; Miller, F.D.; Kaplan, D.R.
    Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse (2003), J. Neurosci., 23, 7602-7609.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Activating Compound

Activating Compound Comment Organism Structure
additional information neurotrophin induces mitogen-activated protein kinase kinase signaling, which is antagonized by semaphorin 3F, Gab-1, an adaptor protein, is recruited by the TrkA kinase to activate MEK in sympathetic neurons, Gab-1 can reverse semaphorin 3F inhibition of the MEK activation Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of Gab-1 in sympathetic neuronal cells leads to increased MEK and ERK activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in the mitogen-activated protein kinase signaling pathway, pathway induction by neurotrophin stabilizes the axonal growth cone, pathway inhibitor semaphorin 3F induces growth cone collaps in sympathetic neurons and reduction of axonal growth ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture from superior cervical ganglia Rattus norvegicus
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ganglion superior cervical Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway, pathway induction by neurotrophin stabilizes the axonal growth cone, pathway inhibitor semaphorin 3F induces growth cone collaps in sympathetic neurons and reduction of axonal growth Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
ERK
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 Rattus norvegicus
extracellular-signal-regulated kinase
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 Rattus norvegicus
MEK
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 Rattus norvegicus
mitogen-activated protein kinase kinase
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 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in vivo assay at Rattus norvegicus