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Literature summary for 2.7.12.2 extracted from

  • Gil, C.; Chaib-Oukadour, I.; Aguilera, J.
    C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons (2003), Biochem. J., 373, 613-620.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Activating Compound

Activating Compound Comment Organism Structure
additional information MEK, ERK-1 and ERK-2 are activated by phosphorylation, tetanus toxin or the C-terminal part of the heavy chain induce phosphorylation of ERK-1 and ERK-2 at Thr202 and Tyr204 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in the mitogen-activated protein kinase signaling pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MEK is phosphorylated at Ser217 and Ser221, activating phosphorylation of ERK-1 and ERK-2 at Thr202 and Tyr204 induced by tetanus toxin or the C-terminal part of the heavy chain Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Rattus norvegicus
-
neuron cultured cortical neurons from fetal brain Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ERK 1
-
 Rattus norvegicus
ERK 2
-
 Rattus norvegicus
extracellular-signal-regulated kinase 1
-
 Rattus norvegicus
extracellular-signal-regulated kinase 2
-
 Rattus norvegicus
MEK
-
 Rattus norvegicus