Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.12.2 extracted from

  • Crews, C.M.; Erikson, R.L.
    Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product (1992), Proc. Natl. Acad. Sci. USA, 89, 8205-8209.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Inhibitors

Inhibitors Comment Organism Structure
additional information inactivated by the serine/threonine phosphatase 2A but not by the protein-tyrosine phosphatase 1B Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P31938
-
-
Mus musculus Q63932
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Erk-1 gene product phosphorylation primarily on a tyrosine residue and, to a lesser extent, on a threonine Mus musculus ADP + phosphorylated Erk-1 gene product
-
 ?
ATP + myelin basic protein kinase
-
 Mus musculus ADP + phosphorylated myelin basic protein kinase
-
 ?
ATP + protein phosphorylates kinase-inactive Erk-1 protein primarily on a tyrosine residue and, to a lesser extent, on a threonine Mus musculus ADP + phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
dual specificity mitogen-activated protein kinase kinase 1
-
 Mus musculus
dual specificity mitogen-activated protein kinase kinase 2
-
 Mus musculus
MAPK/Erk kinase
-
 Mus musculus
MEK
-
 Mus musculus