Literature summary for 2.7.12.2 extracted from

Foltz, I.N.; Gerl, R.E.; Wieler, J.S.; Luckach, M.; Salmon, R.A.; Schrader, J.W.
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli (1998), J. Biol. Chem., 273, 9344-9351.

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Activating Compound

Activating Compound	Comment	Organism	Structure
CD40	activated by ligation of CD40, the B-cell antigen receptor	Homo sapiens
growth factor interleukin-3	activates	Homo sapiens
additional information	enzyme is activated by environmental stress and physiological stimuli. In hematopoietic cells, endogenous MKK7 is activated by treatment with the growth factor interleukin-3, or by ligation of CD40, the B-cell antigen receptor, or the receptor for the Fc fragment of immunoglobulin. MKK7 is also activated when cells are exposed to heat, UV irradiation, anisomycin, hyperosmolarity or the pro-inflammatory cytokine tumor necrosis factor-alpha	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14733	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hematopoietic cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + JNK1	-	Homo sapiens	ADP + phosphorylated JNK1	-	?

Synonyms

Synonyms	Comment	Organism
dual specificity mitogen-activated protein kinase kinase 7	-	Homo sapiens
MKK7	-	Homo sapiens

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Release 2023.1 (January 2023)