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Literature summary for 2.7.12.1 extracted from

  • Guterman-Ram, G.; Pesic, M.; Orenbuch, A.; Czeiger, T.; Aflalo, A.; Levaot, N.
    Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner (2018), J. Cell. Physiol., 233, 617-629 .
    View publication on PubMed
Search for more literature for 2.7.12.1

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92630
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-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte bone marrow monocyte Homo sapiens
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osteoclast
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 Homo sapiens
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RAW-264.7 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
dual specificity tyrosine-phosphorylation-regulated kinase 2
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 Homo sapiens
DYRK2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function Dyrk2 down regulation promotes osteoclast fusion, whereas its overexpression inhibits fusion. Dyrk2 knockdown increases the number of nuclei in osteoclasts. Dyrk2 also promotes the fusion of foreign-body giant cells. Dyrk2 limits the expansion of multinucleated founder cells through the suppression of the fusion competency of follower cells Homo sapiens