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Literature summary for 2.7.12.1 extracted from

  • Miao, R.; Wu, Y.; Zhang, H.; Zhou, H.; Sun, X.; Csizmadia, E.; He, L.; Zhao, Y.; Jiang, C.; Miksad, R.A.; Ghaziani, T.; Robson, S.C.; Zhao, H.
    Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer (2016), Sci. Rep., 6, 33121.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.1

Application

Application Comment Organism
diagnostics the enzyme can act as a bona fide biomarker for liver cancer with prognostic significance in a large cohort of liver cancer patients Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of stable TTK-deficient hepatoccellular carcinoma cells using lentiviral shRNA methods. The cell lines display differential sensitivity to TTK inhibition. Production of TTK deficiency is only possible in Hep-G2 and Huh-7 cell lines, whereas knockdown of TTK is lethal for Hep-3B and PLC/PRL/5 cells. TTK deficiency induces cell death of liver cancer cells in vitro Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P33981
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
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 Homo sapiens
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hepatocellular carcinoma cell levels of TTK protein are significantly elevated in neoplastic tissues from a cohort of liver cancer patients, when compared with adjacent hepatic tissues Homo sapiens
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Huh-7 cell
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 Homo sapiens
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liver levels of TTK protein are significantly elevated in neoplastic tissues from a cohort of liver cancer patients, when compared with adjacent hepatic tissues Homo sapiens
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Synonyms

Synonyms Comment Organism
dual-specificity protein kinase
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 Homo sapiens
TTK
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 Homo sapiens

General Information

General Information Comment Organism
malfunction TTK knockdown inhibits growth, migration and invasiveness of human liver cancer cells in vitro, TTK deficiency induces cell death of liver cancer cells in vitro. In HepG2 cell line, TTK knockdown also results in increased numbers of enlarged viable cells and to significantly increaed levels of LC3-II protein, a sensitive indicator of autophagy. No no difference in overall levels of apoptotic cells, but relative TTK deficiency leads to enhanced senescent and autophagic cell death Homo sapiens
physiological function TTK is a dual-specificity protein kinase that is thought to be involved in mitotic spindle assembly checkpoint and control of cell cycle program. Increased intratumoral expression of TTK correlates with aggressive clinical course and low survival in liver cancer8. TTK has pro-carcinogenic roles in hepatocellular carcinoma development and progression Homo sapiens