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Literature summary for 2.7.12.1 extracted from

  • Abekhoukh, S.; Planque, C.; Ripoll, C.; Urbaniak, P.; Paul, J.-L.; Delabar, J.-M.; Janel, N.
    Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice (2013), Mol. Neurobiol., 47, 105-116.
    View publication on PubMed
Search for more literature for 2.7.12.1

Cloned(Commentary)

Cloned (Comment) Organism
gene DYRK1A, quantitative expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
harmine
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + a phosphoprotein
-
 ?
ATP + extracellular MAP kinase kinase Mus musculus
-
 ADP + phospho-[MAP kinase kinase]
-
 ?
ATP + extracellular signal-regulated kinase Mus musculus
-
 ADP + phospho-[extracellular signal-regulated kinase]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61214
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + a phosphoprotein
-
 ?
ATP + extracellular MAP kinase kinase
-
 Mus musculus ADP + phospho-[MAP kinase kinase]
-
 ?
ATP + extracellular signal-regulated kinase
-
 Mus musculus ADP + phospho-[extracellular signal-regulated kinase]
-
 ?

Synonyms

Synonyms Comment Organism
DYRK1A
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Dyrk1A expression is increased in the brain of cystathionine-beta-synthase (CBS)-deficient mice. The murine model of hyperhomocysteinemia shows an activation of extracellular signal-regulated kinase (ERK) pathway. Significant increase of phosphorylated ERK, phosphorylated MAP kinase kinases, and phosphorylated Akt in the brain of CBS-deficient and Dyrk1A-overexpressing mice. Interaction between Dyrk1A and Grb2 is increased in the brain of Dyrk1A transgenic mice, but Dyrk1A overexpression results in decreased interaction of sprouty 2 and Grb2, and in increased receptor tyrosine kinases phosphorylation and activation, overview Mus musculus
physiological function Dyrk1A is involved in diverse functions ranging from development and growth to apoptosis Mus musculus