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Literature summary for 2.7.12.1 extracted from

  • Huang, S.-H.; Long, M.; Wu, C.-H.; Kwon-Chung, K.J.; Chang, Y.C.; Chi, F.; Lee, S.; Jong, A.
    Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3) (2011), J. Biol. Chem., 286, 34761-34769.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout by anti-DYRK3 siRNA expression in brain microvascular endothelial cells and HeLa cells causing similar phenotypes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lipid raft
-
Homo sapiens
-
-
plasma membrane
-
Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O43781
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
endothelial cell human brain microvascular endothelial cells Homo sapiens
-
erythroid cell DYRK3 is initially identified as an erythroid kinase (REDK), as the gene is expressed preferentially in erythroid cells Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
dual specificity tyrosine phosphorylation-regulated kinase 3
-
Homo sapiens
DYRK3
-
Homo sapiens
erythroid kinase
-
Homo sapiens
REDK
-
Homo sapiens

General Information

General Information Comment Organism
malfunction the endocytic process of invasion of human brain microvascular endothelial cells. Cryptococcus neoformans is abolished by cytochalasin D, nocodazole, or anti-DYRK3 siRNA Homo sapiens
physiological function Cryptococcus neoformans invasion is mediated through the endocytic pathway via lipid rafts.Human CD44 molecules from lipid rafts can directly interact with hyaluronic acid, the Cryptococcus neoformans ligand. Bikunin, which perturbs CD44 function in the lipid raft, can block Cryptococcus neoformans adhesion and invasion of human brain microvascular endothelial cells. Cryptococcus neoformans internalization into human brain microvascular endothelial cells involves the CD44 protein of the hosts, cytoskeleton, and intracellular kinase-DYRK3, overview. Cryptococcus neoformans-induced endocytic dynamics require actin filaments, microtubules, and DYRK3. Effect of DYRK3 on Cryptococcus neoformans transversal across the blood-brain barrier in vitro Homo sapiens