Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockout by anti-DYRK3 siRNA expression in brain microvascular endothelial cells and HeLa cells causing similar phenotypes, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lipid raft | - |
Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43781 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
endothelial cell | human brain microvascular endothelial cells | Homo sapiens | - |
erythroid cell | DYRK3 is initially identified as an erythroid kinase (REDK), as the gene is expressed preferentially in erythroid cells | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
dual specificity tyrosine phosphorylation-regulated kinase 3 | - |
Homo sapiens |
DYRK3 | - |
Homo sapiens |
erythroid kinase | - |
Homo sapiens |
REDK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the endocytic process of invasion of human brain microvascular endothelial cells. Cryptococcus neoformans is abolished by cytochalasin D, nocodazole, or anti-DYRK3 siRNA | Homo sapiens |
physiological function | Cryptococcus neoformans invasion is mediated through the endocytic pathway via lipid rafts.Human CD44 molecules from lipid rafts can directly interact with hyaluronic acid, the Cryptococcus neoformans ligand. Bikunin, which perturbs CD44 function in the lipid raft, can block Cryptococcus neoformans adhesion and invasion of human brain microvascular endothelial cells. Cryptococcus neoformans internalization into human brain microvascular endothelial cells involves the CD44 protein of the hosts, cytoskeleton, and intracellular kinase-DYRK3, overview. Cryptococcus neoformans-induced endocytic dynamics require actin filaments, microtubules, and DYRK3. Effect of DYRK3 on Cryptococcus neoformans transversal across the blood-brain barrier in vitro | Homo sapiens |