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Literature summary for 2.7.12.1 extracted from

  • Kaistha, B.P.; Honstein, T.; Mueller, V.; Bielak, S.; Sauer, M.; Kreider, R.; Fassan, M.; Scarpa, A.; Schmees, C.; Volkmer, H.; Gress, T.M.; Buchholz, M.
    Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells (2014), Br. J. Cancer, 111, 1780-1787.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.1

Cloned(Commentary)

Cloned (Comment) Organism
gene TTK, quantitative real time reverse transcription PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme TTK knockout by siRNA transfection of cell lines PaTu-8988T, Panc1 and S2-028 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P33981
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hTERT-HPNE cell
-
 Homo sapiens
-
Panc1 cell
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic ductal adenocarcinoma cell strong overexpression of dual specificity kinase TTK Homo sapiens
-
PaTu-8988T cell
-
 Homo sapiens
-
S2-028 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
dual specificity kinase
-
 Homo sapiens
Mps1
-
 Homo sapiens
TTK
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens TTK kinase is upregulated in pancreatic cancer up

General Information

General Information Comment Organism
malfunction upon TTK knockdown in pancreatic ductal adenocarcinoma cells, cell proliferation is significantly attenuated, whereas apoptosis and necrosis rates are significantly increased. Anchorage-independent growth, a hallmark of malignant transformation and metastatic potential, is strongly impaired in the absence of TTK gene function. Immortalised normal pancreatic hTERT-HPNE cells are not affected by loss of TTK function. Phenotype, overview. The effects in cancer cells are associated with increased formation of micronuclei, suggesting that loss of TTK function in pancreatic cancer cells results in chromosomal instability and mitotic catastrophe Homo sapiens
physiological function enzyme TTK function is critical for growth and proliferation of pancreatic cancer cells Homo sapiens