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Literature summary for 2.7.12.1 extracted from

  • Scales, T.M.; Lin, S.; Kraus, M.; Goold, R.G.; Gordon-Weeks, P.R.
    Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons (2009), J. Cell Sci., 122, 2424-2435.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + microtubule associated protein 1B Rattus norvegicus DYRK1A phosphorylates the S1392 site on microtubule associated protein 1B ADP + phosphorylated microtubule associated protein 1B
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + microtubule associated protein 1B DYRK1A phosphorylates the S1392 site on microtubule associated protein 1B Rattus norvegicus ADP + phosphorylated microtubule associated protein 1B
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 ?

Synonyms

Synonyms Comment Organism
dual-specificity tyrosine-phosphorylation-regulated kinase
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 Rattus norvegicus
DYRK1A
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
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 Rattus norvegicus

General Information

General Information Comment Organism
malfunction knockdown of DYRK1A in cortical neurons disrupts neuritogenesis and alters microtubule stability Rattus norvegicus
physiological function DYRK1A primes S1388, a glycogen synthase kinase 3beta phosphorylation sites on microtubule associated protein 1B Rattus norvegicus