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Literature summary for 2.7.12.1 extracted from

  • Arque, G.; Fotaki, V.; Fernandez, D.; Martinez de Lagran, M.; Arbones, M.L.; Dierssen, M.
    Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A) (2008), PLoS ONE, 3, e2575.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q61214 wild-type and transgenic mice, mice heterozygous for a Dyrk1A targeted mutation (Dyrk1A+/2), maintained in a C57BL/6J-129Ola (C57-129) mixed genetic background
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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mice heterozygous for a Dyrk1A targeted mutation (Dyrk1A+/2) and wild-type, behavioral tests, non-searching and learning strategies in the Morris water maze test, swimming test, object recognition test, profound effect on phenotype by removal of single gene, haploinsufficiency of DYRK1A might contribute to an impairment of cognitive functions and stress coping behavior in human monosomy 21 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role of Dyrk1A in cognitive phenotypes of monosomy 21 Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
DYRK1A
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Mus musculus