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Literature summary for 2.7.12.1 extracted from

  • Ryoo, S.R.; Cho, H.J.; Lee, H.W.; Jeong, H.K.; Radnaabazar, C.; Kim, Y.S.; Kim, M.J.; Son, M.Y.; Seo, H.; Chung, S.H.; Song, W.J.
    Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimers disease (2008), J. Neurochem., 104, 1333-1344.
    View publication on PubMed
Search for more literature for 2.7.12.1

Application

Application Comment Organism
medicine potential link between Down syndrome and Alzheimers disease by activity of DYRK1A, overexpression of DYRK1A in patients with Down syndrome may play a role in accelerating pathogenesis of Alzheimers disease through phosphorylation of the beta-amyloid (Ab) precursor protein APP, therapeutics that inhibit DYRK1A expression and/or kinase activity suggested as a possibility to suppress the early-onset of Alzheimers disease and mental retardation in Down syndrome patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) codon plus RIL, plasmid pcDNA3.1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13627
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration, SDS-PAGE Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain expressed in Homo sapiens
-
HEK-293T cell transfection analysis Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 phosphorylation of the beta-amyloid (Ab) precursor protein APP at the threonine residue 668 by DYRK1A shown in vitro and in mammalian cells, overexpression of the human DYRK1A protein in transgenic mice reveals increased amounts of phophorylated APP precursor protein, increased amounts of phosphorylated APP precursor protein in brains of Down syndrome patients Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DYRK1A-mediated phosphorylation of the beta-amyloid (Ab) precursor protein APP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DYRK1A
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens