Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.12.1 extracted from

  • Shi, J.; Zhang, T.; Zhou, C.; Chohan, M.O.; Gu, X.; Wegiel, J.; Zhou, J.; Hwang, Y.W.; Iqbal, K.; Grundke-Iqbal, I.; Gong, C.X.; Liu, F.
    Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome (2008), J. Biol. Chem., 283, 28660-28669.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.1

Application

Application Comment Organism
medicine involvement of early onset tauopathy in individuals with Down syndrome, research and development of therapeutics for tauopathies Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant Dyrk1A-protein expressed in mammalian expression vector pcDNA3, wild-type and mutant Homo sapiens

Protein Variants

Protein Variants Comment Organism
K188R kinase-dead Dyrk1A construct Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13627 Homo sapiens; adult individuals with Down syndrome
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain expression analysis in Homo sapiens
-
HEK-293T cell co-transfection studies in Homo sapiens
-
HeLa cell co-localization study in Homo sapiens
-
SH-SY5Y cell co-expression experiments in Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 imbalance of 3R-tau and 4R-tau proteins attributed to Dyrk1A-induced dysregulation of alternative splicing factor (ASF), Dyrk1A phosphorylates alternative splicing factor (ASF) at Ser-227, Ser-234, and Ser-238, Dyrk1A inhibits the role of alternative splicing factor (ASF) in tau exon 10 inclusion, splicing of exon 10 of tau protein quantified, interaction between alternative splicing factor (ASF) and Dyrk1A, model for the inhibitory role of Dyrk1A in tau exon 10 inclusion via phosphorylation of ASF Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information increased dosage of Dyrk1A in brains of individuals with Down syndrome (DS) correlates to increased level of 3R-tau protein, abnormal hyperphosphorylation and aggregation of tau proteins, leads to neurofibrillary degeneration in Down syndrome Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DYRK1A
-
 Homo sapiens