Literature summary for 2.7.12.1 extracted from

Guimera, J.; Casas, C.; Pucharcos, C.; et al.
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region (1996), Hum. Mol. Genet., 5, 1305-1310.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + SR protein	Homo sapiens	MNB protein may play a significant role in a signaling pathway regulating nuclear functions of neuronal cell proliferation, contributing to certain features of Down syndrome	ADP + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13627	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	expressed in the neuronal regions affected in Down syndrome	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + SR protein	MNB protein may play a significant role in a signaling pathway regulating nuclear functions of neuronal cell proliferation, contributing to certain features of Down syndrome	Homo sapiens	ADP + ?	-	?

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Release 2023.1 (January 2023)