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Literature summary for 2.7.11.9 extracted from

  • Miralem, T.; Gibbs, P.E.; Revert, F.; Saus, J.; Maines, M.D.
    Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression (2010), J. Biol. Chem., 285, 12551-12558.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.9

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha stimulates the autophosphorylation of Goodpasture antigen-binding protein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
human biliverdin reductase i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [Goodpasture antigen-binding protein] Homo sapiens the Goodpasture antigen-binding protein performs autophosphorylation ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Goodpasture antigen-binding protein performs autophosphorylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [Goodpasture antigen-binding protein] the Goodpasture antigen-binding protein performs autophosphorylation Homo sapiens ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
Goodpasture antigen-binding protein kinase
-
 Homo sapiens
GPBP kinase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase up

General Information

General Information Comment Organism
metabolism downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase Homo sapiens