Literature summary for 2.7.11.9 extracted from

Revert, F.; Ventura, I.; Martinez-Martinez, P.; Granero-Molto, F.; Revert-Ros, F.; Macias, J.; Saus, J.
Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen: identification of novel membrane-bound isoforms (2008), J. Biol. Chem., 283, 30246-30255.

Cloned(Commentary)

Cloned (Comment)	Organism
gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview	Homo sapiens

Cloned (Comment)

Organism

gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview

Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	isozyme GPBPDELTA26/CERT	Homo sapiens	5829	-
endoplasmic reticulum	91 kDa GPBP	Homo sapiens	5783	-
extracellular	77 kDa GPBP	Homo sapiens	-	-
Golgi apparatus	91 kDa GPBP	Homo sapiens	5794	-
membrane	91 kDa GPBP	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + membrane type IV collagen	Homo sapiens	GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment	ADP + phopshorylated membrane type IV collagen	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y5P4	gene COL4A3BP	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + membrane type IV collagen	GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment	Homo sapiens	ADP + phopshorylated membrane type IV collagen	-	?
ATP + membrane type IV collagen	Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen	Homo sapiens	ADP + phopshorylated membrane type IV collagen	-	?

Synonyms

Synonyms	Comment	Organism
GPBP	-	Homo sapiens
GPBPDELTA26/CERT	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens