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Literature summary for 2.7.11.7 extracted from

  • Steimle, P.A.; Licate, L.; Cote, G.P.; Egelhoff, T.T.
    Lamellipodial localization of Dictyostelium myosin heavy chain kinase A is mediated via F-actin binding by the coiled-coil domain (2002), FEBS Lett., 516, 58-62.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
construction of His-tagged or GFP fusion proteins with the full length enzyme or enzyme fragments, expression in Dictyostelium discoideum cells Dictyostelium discoideum

Protein Variants

Protein Variants Comment Organism
C800A catalytic domain mutation, no remaining activity when expressed as full length enzyme or as catalytic domain only in a deficient Dictyostelium discoideum cell line Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
cell cortex
-
Dictyostelium discoideum 5938
-
cytosol
-
Dictyostelium discoideum 5829
-
lamellipodium
-
Dictyostelium discoideum 30027
-
additional information translocation of the enzyme within the cell responding to outer signals Dictyostelium discoideum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin II heavy chain Dictyostelium discoideum key role in regulating myosin localization ADP + myosin II heavy chain phosphate
-
?
ATP + myosin II heavy chain Dictyostelium discoideum the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin ADP + myosin II heavy chain phosphate
-
?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum P42527 myosin II heavy chain kinase MHCK A
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged or GFP-fusion proteins from Dictyostelium discoideum Dictyostelium discoideum

Reaction

Reaction Comment Organism Reaction ID
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate enzyme contains the C-terminal WD-domain, responsible for substrate binding, the catalytic domain, and the N-terminal coiled-coil translocation domain Dictyostelium discoideum

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin heavy chain kinase intramolecular autophosphorylation Dictyostelium discoideum ADP + myosin heavy chain kinase phosphate
-
?
ATP + myosin II heavy chain
-
Dictyostelium discoideum ADP + myosin II heavy chain phosphate
-
?
ATP + myosin II heavy chain key role in regulating myosin localization Dictyostelium discoideum ADP + myosin II heavy chain phosphate
-
?
ATP + myosin II heavy chain the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin Dictyostelium discoideum ADP + myosin II heavy chain phosphate
-
?

Synonyms

Synonyms Comment Organism
MHCK
-
Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Dictyostelium discoideum