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Literature summary for 2.7.11.7 extracted from

  • Wang, Z.Y.; Brzeska, H.; Baines, I.C.; Korn, E.D.
    Properties of Acanthamoeba myosin I heavy chain kinase bound to phospholipid vesicles (1995), J. Biol. Chem., 270, 27969-27976.
    View publication on PubMed
Search for more literature for 2.7.11.7

Activating Compound

Activating Compound Comment Organism Structure
acidic phospholipids enhance the activation of the enzyme by autophosphorylation Acanthamoeba castellanii
additional information enzyme is stimulated by its autophosphorylation Acanthamoeba castellanii
phosphatidylserine
-
 Acanthamoeba castellanii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 myosin IB soluble, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.0003
-
 myosin IA soluble, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.0005
-
 myosin IB phospholipid-bound, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.0007
-
 myosin IA phospholipid-bound, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.0023
-
 myosin IA soluble, phosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.0055
-
 myosin IB soluble, phosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.064
-
 GRGRSSVYS phospholipid-bound, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.064
-
 GRGRSSVYS soluble, phosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii
0.11
-
 GRGRSSVYS soluble, unphosphorylated enzyme, pH 7.0, 30°C Acanthamoeba castellanii

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane binding to the plasma membrane enhances the activity of unphosphorylated enzyme 20fold, substrate myosin I Acanthamoeba castellanii 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Acanthamoeba castellanii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin I heavy chain Acanthamoeba castellanii
-
 ADP + myosin I heavy chain phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Acanthamoeba castellanii
-
 myosin I heavy chain kinase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GRGRSSVYS
-
 Acanthamoeba castellanii ADP + GRGRSS(-phosphate)VYS
-
 ?
ATP + myosin heavy chain kinase intermolecular autophosphorylation with vesicle-bound enzyme in absence of substrates Acanthamoeba castellanii ADP + myosin heavy chain kinase phosphate
-
 ?
ATP + myosin heavy chain kinase leads to activation of the phosphorylation activity towards myosin I Acanthamoeba castellanii ADP + myosin heavy chain kinase phosphate
-
 ?
ATP + myosin I heavy chain
-
 Acanthamoeba castellanii ADP + myosin I heavy chain phosphate
-
 ?
ATP + myosin I heavy chain higher activity with membrane-bound substrate myosin I Acanthamoeba castellanii ADP + myosin I heavy chain phosphate
-
 ?
ATP + myosin I heavy chain substrates are heavy chains of myosin IA and IB Acanthamoeba castellanii ADP + myosin I heavy chain phosphate
-
 ?
ATP + myosin IA
-
 Acanthamoeba castellanii ADP + myosin IA phosphate
-
 ?
ATP + myosin IB
-
 Acanthamoeba castellanii ADP + myosin IB phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MHCK
-
 Acanthamoeba castellanii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Acanthamoeba castellanii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Acanthamoeba castellanii

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Acanthamoeba castellanii