Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DNA | autophosphorylation activity is increased 5-10fold in a Ca2+-independent manner | Dictyostelium discoideum | |
heparin | autophosphorylation activity is increased 5-10fold in a Ca2+-independent manner | Dictyostelium discoideum | |
additional information | - |
Dictyostelium discoideum | |
Phospholipid vesicles | autophosphorylation activity is increased 5-10fold in a Ca2+-independent manner | Dictyostelium discoideum | |
Phospholipid vesicles | composed of phosphatidylserine or phosphatidylinositol, not phosphatidylcholine | Dictyostelium discoideum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
histone | - |
Dictyostelium discoideum | |
Positively charged polypeptides | strong inhibition, e.g. poly-(D-Lys), poly-(L-Lys), poly-(L-Arg) of different molecular weights | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Dictyostelium discoideum | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | not required | Dictyostelium discoideum | |
Mg2+ | requirement | Dictyostelium discoideum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin I heavy chain | Dictyostelium discoideum | involved in regulation of myosin II filament assembly | ADP + myosin I heavy chain phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
two heavy chain kinases: one in growth-phase cells and one in starved, developing cells | - |
Dictyostelium discoideum | - |
gene MHCK A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | growth-phase cells contain enzyme form MHCK A | Dictyostelium discoideum | - |
cell culture | starved-developing cells contain enzyme form MHCK B | Dictyostelium discoideum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin heavy chain kinase | intramolecular autophosphorylation | Dictyostelium discoideum | ADP + myosin heavy chain kinase phosphate | - |
? | |
ATP + myosin heavy chain kinase | leads to activation of the phosphorylation activity towards myosin I | Dictyostelium discoideum | ADP + myosin heavy chain kinase phosphate | - |
? | |
ATP + myosin I heavy chain | phosphorylation of residues Thr1833 and Thr2029 | Dictyostelium discoideum | ADP + myosin I heavy chain phosphate | - |
? | |
ATP + myosin I heavy chain | phosphorylates threonine residues | Dictyostelium discoideum | ADP + myosin I heavy chain phosphate | - |
? | |
ATP + myosin I heavy chain | involved in regulation of myosin II filament assembly | Dictyostelium discoideum | ADP + myosin I heavy chain phosphate | - |
? | |
ATP + synthetic peptides | peptide MH-3, corresponding to myosin II heavy chain from residues 2020 to 2035 except that Ser-2026 and Thr-2031 have been replaced by alanine | Dictyostelium discoideum | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Dictyostelium discoideum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Dictyostelium discoideum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Dictyostelium discoideum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition by positively charged polypeptides | Dictyostelium discoideum |