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Literature summary for 2.7.11.5 extracted from

  • Ikeda, T.P.; Houtz, E.; LaPorte, D.C.
    Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity (1992), J. Bacteriol., 174, 1414-1416.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.5

Cloned(Commentary)

Cloned (Comment) Organism
bifunctional protein, expressed from the aceK gene Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli W3550 reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 wild-type and mutants
-
Escherichia coli W3550
-
 wild-type and mutants
-

Purification (Commentary)

Purification (Comment) Organism
partial, bifunctional protein Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.11 0.63
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli W3550 ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways Escherichia coli W3550 ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r

Synonyms

Synonyms Comment Organism
IDH kinase/phosphatase
-
 Escherichia coli