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Literature summary for 2.7.11.4 extracted from

  • Paxton, R.; Harris, R.A.
    Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart (1984), Arch. Biochem. Biophys., 231, 58-66.
    View publication on PubMed
Search for more literature for 2.7.11.4

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyphenylacetate
-
 Oryctolagus cuniculus
4-hydroxyphenyllactate weak Oryctolagus cuniculus
4-hydroxyphenylpyruvate very weak: 3-hydroxyphenylpyruvate Oryctolagus cuniculus
acetate weak, in vivo and in vitro Oryctolagus cuniculus
Clofibric acid in vivo and in vitro Oryctolagus cuniculus
Dichloroacetate
-
 Oryctolagus cuniculus
Dichloroacetate
-
 Rattus norvegicus
additional information no inhibition by lactate Oryctolagus cuniculus
additional information
-
 Rattus norvegicus
phenylacetate strong Oryctolagus cuniculus
Phenyllactate strong Oryctolagus cuniculus
phenylpyruvate in vivo and in vitro Oryctolagus cuniculus
pyruvate weak Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Rattus norvegicus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?