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Literature summary for 2.7.11.31 extracted from

  • Sano, S.; Sakagami, R.; Sekiguchi, M.; Hidaka, M.
    Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O6-methylguanine-induced apoptosis (2013), Biochem. Biophys. Res. Commun., 430, 810-815.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
compound C a specific inhibitor of AMPK Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13131
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
heterotrimer enzyme AMPK is composed of AMPKalpha, beta and gamma subunits Homo sapiens

Synonyms

Synonyms Comment Organism
5'-AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens
AMPKalpha
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction stabilization of MAPO1 occurs in AMPKalpha-knockdown cells even without N-methyl-N-nitrosourea treatment. Knockdown of the Flcn and Ampkalpha genes by specific siRNAs significantly suppresses an apoptotic response to N-methyl-N-nitrosourea Homo sapiens
physiological function AMPK is a cellular energy sensor that negatively regulates cell growth and proliferation. MAPO1, identified as a component involved in the induction of apoptosis, is stabilized by interaction with AMP-activated protein kinase (AMPK) and folliculin (FLCN). AMPK is activated during the process of O6-methylguanine-induced apoptosis and this activation is dependent on MAPO1 and folliculin. It is likely that the kinase activity of AMPK is involved in the degradation of MAPO1 Homo sapiens