Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13131 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | autophosphorylation of 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 3-mercaptopyruvate sulfurtransferase | - |
Homo sapiens | ADP + phosphorylated 3-mercaptopyruvate sulfurtransferase | - |
? | |
ATP + acylamino-acid-releasing enzyme | - |
Homo sapiens | ADP + phosphorylated acylamino-acid-releasing enzyme | - |
? | |
ATP + adenylate kinase isoenzyme 1 | - |
Homo sapiens | ADP + phosphorylated adenylate kinase isoenzyme 1 | - |
? | |
ATP + band 3 anion transport protein | - |
Homo sapiens | ADP + phosphorylated band 3 anion transport protein | - |
? | |
ATP + beta actin | - |
Homo sapiens | ADP + phosphorylated beta actin | - |
? | |
ATP + bisphosphoglycerate mutase | - |
Homo sapiens | ADP + phosphorylated bisphosphoglycerate mutase | - |
? | |
ATP + carbonic anhydrase 1 | - |
Homo sapiens | ADP + phosphorylated carbonic anhydrase 1 | - |
? | |
ATP + catalase | - |
Homo sapiens | ADP + phosphorylated catalase | - |
? | |
ATP + cytoplasmic malate dehydrogenase | - |
Homo sapiens | ADP + phosphorylated cytoplasmic malate dehydrogenase | - |
? | |
ATP + dihydropteridine reductase | - |
Homo sapiens | ADP + phosphorylated dihydropteridine reductase | - |
? | |
ATP + DNA damage-binding protein 1 | - |
Homo sapiens | ADP + phosphorylated DNA damage-binding protein 1 | - |
? | |
ATP + erythrocyte spectrin alpha chain | - |
Homo sapiens | ADP + phosphorylated erythrocyte spectrin alpha chain | - |
? | |
ATP + erythrocyte spectrin beta chain | - |
Homo sapiens | ADP + phosphorylated erythrocyte spectrin beta chain | - |
? | |
ATP + flavin reductase | - |
Homo sapiens | ADP + phosphorylated flavin reductase | - |
? | |
ATP + glutathione S-transferase omega-1 | - |
Homo sapiens | ADP + phosphorylated glutathione S-transferase omega-1 | - |
? | |
ATP + glutathione synthetase | - |
Homo sapiens | ADP + phosphorylated glutathione synthetase | - |
? | |
ATP + peroxiredoxin-2 | - |
Homo sapiens | ADP + phosphorylated peroxiredoxin-2 | - |
? | |
ATP + peroxiredoxin-6 | - |
Homo sapiens | ADP + phosphorylated peroxiredoxin-6 | - |
? | |
ATP + phosphoglycerate kinase 1 | - |
Homo sapiens | ADP + phosphorylated phosphoglycerate kinase 1 | - |
? | |
ATP + phosphoribosylformylglycinamidine synthase | - |
Homo sapiens | ADP + phosphorylated phosphoribosylformylglycinamidine synthase | - |
? | |
ATP + proteasome subunit alpha type-1 | - |
Homo sapiens | ADP + phosphorylated proteasome subunit alpha type-1 | - |
? | |
ATP + proteasome subunit alpha type-7 | - |
Homo sapiens | ADP + phosphorylated proteasome subunit alpha type-7 | - |
? | |
ATP + purine nucleoside phosphorylase | - |
Homo sapiens | ADP + phosphorylated purine nucleoside phosphorylase | - |
? | |
ATP + S-formylglutathione hydrolase | - |
Homo sapiens | ADP + phosphorylated S-formylglutathione hydrolase | - |
? | |
ATP + selenium binding protein 1 | - |
Homo sapiens | ADP + phosphorylated selenium binding protein 1 | - |
? | |
ATP + thioredoxin-like protein 1 | - |
Homo sapiens | ADP + phosphorylated thioredoxin-like protein 1 | - |
? | |
ATP + transaldolase | - |
Homo sapiens | ADP + phosphorylated transaldolase | - |
? | |
ATP + transferrin | - |
Homo sapiens | ADP + phosphorylated transferrin | - |
? | |
ATP + ubiquitin carboxyl-terminal hydrolase 13 | - |
Homo sapiens | ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 13 | - |
? | |
ATP + ubiquitin carboxyl-terminal hydrolase 14 | - |
Homo sapiens | ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 14 | - |
? | |
ATP + ubiquitin carboxyl-terminal hydrolase 5 | - |
Homo sapiens | ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 5 | - |
? | |
ATP + ubiquitin-activating enzyme E1 | - |
Homo sapiens | ADP + phosphorylated ubiquitin-activating enzyme E1 | - |
? | |
ATP + valosin-containing protein | - |
Homo sapiens | ADP + phosphorylated valosin-containing protein | - |
? | |
additional information | identification of putative AMPK targets in hemoglobin-depleted lysates of erythrocytes, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response, cloning and recombinant expression | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5'-AMP-activated protein kinase catalytic subunit alpha-1 | - |
Homo sapiens |
AMP-activated protein kinase | - |
Homo sapiens |
AMPK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the absence of functional AMPK may consequently cause a failure of distinct signaling pathways in red bood cells | Homo sapiens |
physiological function | AMPK is a metabolic stress-sensing kinase with important functions for red blood cell survival. Identification of putative AMPK targets in hemoglobin-depleted lysates of erythrocytes, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response, cloning and recombinant expression. AMPK aids the function of red blood cells | Homo sapiens |