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Literature summary for 2.7.11.31 extracted from

  • Zhang, H.S.; Wu, M.R.
    SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase (2009), Virus Res., 146, 51-57.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide ribonucleoside AICAR, AMPK activator, inhibits Tat-induced HIV-1 transactivation Homo sapiens
resveratrol reverses Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation, inhibits Tat-induced HIV-1 transactivation Homo sapiens

Application

Application Comment Organism
drug development targeting SIRT1-AMPK pathway may serve as a new target for the development of new anti HIV-1 agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine compound C, potentiates Tat-induced HIV-1 transactivation Homo sapiens
additional information a significant reduction in AMPK activation and downstream acetyl-CoA carboxylase activation in response to viral Tat protein treatment. Knockdown of SIRT1 by siRNA potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Knockdown of AMPK by siRNA potentiates Tat-induced HIV-1 transactivation Homo sapiens
nicotinamide SIRT1 inhibitor, potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Potentiates Tat-induced HIV-1 transactivation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA carboxylase
-
 Homo sapiens ADP + phosphorylated acetyl-CoA carboxylase
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens